(E)-C-HDMAPP (ammonium salt) T38039
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 933030-60-5 | ¥2,520.00 | 询底价 |
5 mg | 933030-60-5 | ¥10,500.00 | 询底价 |
10 mg | 933030-60-5 | ¥17,100.00 | 询底价 |
500 μg | 933030-60-5 | ¥1,330.00 | 询底价 |
Product Introduction
Bioactivity
英文名: (E)-C-HDMAPP (ammonium salt)
描述: Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells. (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation. (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM. (E)-C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: PBS (pH 7.2) : 10 mg/mL
关键字: (E)CHDMAPP (ammonium salt) | C-HDMAPP | (E) C HDMAPP (ammonium salt)
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途