Resolvin E4 T38043
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 μg | 1781227-87-9 | ¥2,110.00 | 询底价 |
25 μg | 1781227-87-9 | ¥4,770.00 | 询底价 |
50 μg | 1781227-87-9 | ¥8,970.00 | 询底价 |
100 μg | 1781227-87-9 | ¥15,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Resolvin E4
描述: Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediatesin vitroand by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism. It has been found in mouse inflammatory exudates. RvE4 (10 nM) increases efferocytosis of apoptotic neutrophils or senescent red blood cells (sRBCs) by human M2 macrophages under hypoxic conditionsin vitro. Intraperitoneal administration of RvE4 (100 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of hemorrhagic peritonitis induced by zymosan A and thrombin. It also increases inflammatory exudate macrophage infiltration and efferocytosis of apoptotic neutrophils and/or RBCs in the same model.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMF : 50 mg/mL
Ethanol : 50 mg/mL
PBS (pH 7.2) : 0.05 mg/mL
关键字: Resolvin E4 | Resolvin E-4
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途