化合物N-Acetyl lysyltyrosylcysteine amide acetate T38063L

Product Introduction
Bioactivity


英文名: N-Acetyl lysyltyrosylcysteine amide acetate

描述: N-Acetyl lysyltyrosylcysteine amide acetate 是一种有效且特异性的髓过氧化物酶 (MPO) 三肽抑制剂。 N-Acetyl lysyltyrosylcysteine amide acetate 抑制 MPO 依赖性次氯酸的生成、蛋白质硝化和 LDL 氧化反应。 N-Acetyl lysyltyrosylcysteine amide acetate 可减少中风后大脑中的神经元损伤并保护脑组织和神经功能。

体内活性: N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: NAcetyl lysyltyrosylcysteine amide acetate | N-Acetyl lysyltyrosylcysteine amide Acetate | N Acetyl lysyltyrosylcysteine amide acetate

相关产品: Mitiperstat | ML162 | MPO-IN-28 | ML-210 | PF-06282999 | Moracin N | RSL3 | Melatonin | NBDHEX | PF-1355

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