3'-sulfo Galactosylsphingosine (ammonium salt) T38090

Product Introduction
Bioactivity


英文名: 3'-sulfo Galactosylsphingosine (ammonium salt)

描述: 3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM. It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 μM, respectively. 3'-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) deficiency leading to progressive demyelination and neuromotor deficits. In mice lacking ASA, levels of 3'-sulfo galactosylsphingosine increase after one month of age followed by demyelination and neuromotor deficits. 3'-sulfo Galactosylsphingosine has been used as a standard for the quantification of 3'-sulfo galactosylsphingosine by LC-MS.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Chloroform:Methanol (2:1) : Soluble


关键字: 3'sulfo Galactosylsphingosine (ammonium salt) | 3' sulfo Galactosylsphingosine (ammonium salt) | 3'-sulfo Galactosylsphingosine

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