2'-脱氧-2-氟胞苷 T38238

Product Introduction
Bioactivity


英文名: 2'-Deoxy-2'-fluorocytidine

描述: 2'-Deoxy-2'-fluorocytidine 是一种核苷类似物，可有效抑制刚果出血热病毒的复制。2'-Deoxy-2'-fluorocytidine 与 T705 的协同作用会增强对CCHFV 复制的抵抗效力。

体外活性: 2'-Deoxy-2'-fluorocytidine (EC50 = 61 ± 18 nM) has 200 × the potency of ribavirin (EC50 = 12.5 ± 2.6 μM), as well as 17 × the potency of T-705 (favipiravir), another compound with reported anti-CCHFV activity (EC50 = 1.03 ± 0.16 μM). 2'-Deoxy-2'-fluorocytidine acts synergistically with T-705 to inhibit CCHFV replication without causing cytotoxicity[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (203.91 mM)
H2O : 5 mg/mL (20.39 mM)


关键字: Crimean-Congo hemorrhagic fever | 2' Deoxy 2' fluorocytidine | Inhibitor | nucleoside analog | inhibit | Influenza Virus | 2'Deoxy2'fluorocytidine | Antiviral,CCHFV | 2'-Deoxy-2'-fluorocytidine

相关产品: ddUTP (lithium), 100mM in H2O | Dacarbazine | SIBA | 3'-Deoxy-3'-fluoroguanosine | LY2334737 | Deoxyguanosine triphosphate trisodium salt | Sangivamycin | RX-3117 | N6-Methyl-2'-O-methyladenosine | Deoxycytidine triphosphate

相关库: Nucleotide Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | DNA Damage & Repair Compound Library | Covalent Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library

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