Sparstolonin B T38261
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 1259330-61-4 | ¥1,730.00 | 询底价 |
100 mg | 1259330-61-4 | ¥12,200.00 | 询底价 |
25 mg | 1259330-61-4 | ¥6,290.00 | 询底价 |
50 mg | 1259330-61-4 | ¥8,170.00 | 询底价 |
1 mL | 1259330-61-4 | ¥2,560.00 | 询底价 |
2 mg | 1259330-61-4 | ¥987.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Sparstolonin B
描述: Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacological properties, including anti-HIV and anticancer activities[1][2].
体外活性: Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells[3].Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2[1].Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells[3]. Cell Viability Assay[3] Cell Line: SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells
体内活性: Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice[1]. Animal Model: 5-6-week-old male C57Bl/6 mice (body weight 18-20 g)[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Sparstolonin B
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途