Patamostat mesylate T38521

Product Introduction
Bioactivity


英文名: Patamostat mesylate

描述: Patamostat mesylate (E-3123) is a highly potent protease inhibitor, displaying strong inhibitory activity against trypsin, plasmin, and thrombin, with IC 50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compound, Patamostat mesylate, shows promising potential in suppressing the pathogenesis and development of acute pancreatitis.

体内活性: Patamostat mesylate (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner[1]. Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis[1]. Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats[2]. Animal Model: Male Wistar rats weighing about 350 g[2]Dosage: 2 mg/kg Administration: Continuous infusion per h for 1 h Result: Significantly improved the survival rate.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Patamostat mesylate | Patamostat Mesylate | E3123 Mesylate | E 3123 Mesylate | E-3123 Mesylate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途