β-桉叶醇 T3865

Product Introduction
Bioactivity


英文名: beta-Eudesmol

描述: beta-Eudesmol (Beta-Selinenol) 是天然的含氧倍半萜烯，可激活hTRPA1，EC50值为 32.5 μM。Beta-Eudesmol 有增加食欲的功效。

体外活性: β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs) that decreases the open time and opening frequency of nAChR channels when used at concentrations of 40 and 80 μM and increases the decay phase of the depolarization when used at a concentration of 100 μM in isolated mouse diaphragm muscle [1]. β-Eudesmol (50-100 μM) inhibits VEGF- and bFGF-induced proliferation in human umbilical vein endothelial cells (HUVECs) [2].

体内活性: β-Eudesmol also inhibits proliferation of HeLa, SGC-7901, and BEL-7402 cells when used at concentrations ranging from 10 to 100 μM and reduces tumour growth in H22 and S-180 mouse tumor models when administered at doses ranging from 2.5 to 5 mg/kg. β-Eudesmol is an agonist of the transient receptor potential (TRP) receptor subtypes TRPA1, TRPV3, and TRPM8 and increases food intake and plasma levels of ghrelin in rats [3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (112.42 mM)


关键字: β-Eudesmol | inhibit | Transient receptor potential channels | b-Eudesmol | β-Selinenol | betaEudesmol | TRP Channel | Beta-Eudesmol | beta-Eudesmol | beta Eudesmol | Inhibitor | b-Selinenol

相关产品: TC-I 2014 | JNJ-17203212 | ICILIN | A-967079 | Palvanil | TC-I2000 | Adenosine 5'-diphosphoribose sodium | AC1903 | SB-705498 | ABT-239

相关库: Ion Channel Inhibitor Library | Anti-Neurodegenerative Disease Compound Library | Tobacco Monomer Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Alzheimer's Disease Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途