化合物Tat-beclin 1 acetate T38861L

Product Introduction
Bioactivity


英文名: Tat-beclin 1 acetate

描述: Tat-beclin 1 acetate 是一种有效的自噬诱导剂，并与自噬的负调节因子 GAPR-1 相互作用。 Tat-beclin 1 acetate 减少聚谷氨酰胺扩增蛋白聚集体的积累和几种病原体（包括 HIV-1）的复制。

体外活性: Tat-beclin 1 acetate (10 μM; 2-4 hours post-infection) decreases the intracellular survival of L. monocytogenes in primary murine bone-marrow-derived macrophages (BMDMs)[1]. Tat-beclin 1 acetate (10, 30, 50 μM; 24 hours) induces autophagy and results in a dose-dependent decrease in amounts of p62, a selective autophagy substrate, and a dose-dependent conversion of the non-lipidated form of LC3, LC3-I, to the lipidated, autophagosome-associated form of LC3, LC3-II, in multiple cell lines and primary murine embryonic fibroblasts (MEFs)[1].

体内活性: Tat-beclin 1 acetate reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV). Tat-beclin 1 acetate (15 mg/kg; i.p.) induces autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice[1].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45.00mg/ml


关键字: Tat beclin 1 acetate | Tat-beclin 1 Acetate | Tatbeclin 1 acetate

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相关库: Peptide Compound Library

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