化合物IHVR-17028 T38894
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 1428247-78-2 | ¥5,220.00 | 询底价 |
25 mg | 1428247-78-2 | ¥11,200.00 | 询底价 |
100 mg | 1428247-78-2 | ¥17,500.00 | 询底价 |
500 mg | 1428247-78-2 | ¥34,800.00 | 询底价 |
1 mg | 1428247-78-2 | ¥2,350.00 | 询底价 |
5 mg | 1428247-78-2 | ¥5,630.00 | 询底价 |
10 mg | 1428247-78-2 | ¥7,790.00 | 询底价 |
50 mg | 1428247-78-2 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: IHVR-17028
描述: IC50 为 0.24 μMIHVR-17028 是一种有效的广谱的 ER α-葡萄糖苷酶 I (α-glucosidase?I) 抑制剂,IC50 为 0.24 μM,具有抗病毒活性。 IHVR-17028 对 BVDV、TCRV 和 DENV 具有抑制作用, EC50 分别为0.4 μM、0.26 μM 和0.3 μM。IHVR-17028 可用于研究传染病。
体外活性: IHVR-17028 demonstrates potent antiviral activity against bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), and DENV (serotype 2, New Guinea C) with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively, in virus yield reduction assays. Furthermore, IHVR-17028 exhibits high cell viability with IC50 values exceeding 500 μM in MDBK, Huh7.5, and BHK cells, as determined by MTT assays.[1]
体内活性: In rats, during pharmacokinetic analysis, IHVR17028 (75 mg/kg, oral gavage) demonstrates a C max value of 0.18 μg/ml. The T max value is 1.56 hours, and after PO administration, the F% value is 12%. The T 1/2 value is 0.88 hours after iv administration[1].In a mouse model of lethal MARV infection, IHVR-17028 treatment (25-50 mg/kg, oral gavage) one day before virus challenging exhibits significant protection.[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 30 mg/mL (69.99 mM)
关键字: IHVR-17028 | IHVR17028 | IHVR 17028
相关产品: Diphyllin | Neuraminidase-IN-13 | Loratadine | SP187 | BMY-27709 | Geniposide | Cinanserin hydrochloride | Nitazoxanide | Oxymatrine | Aprotinin
相关库: Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途