WAY-100135 dihydrochloride T38975

Product Introduction
Bioactivity


英文名: WAY-100135 dihydrochloride

描述: WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compound displays promising antipsychotic effects.

体外活性: WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA 2 of 7.2[1]. WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons[2].

体内活性: WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats[1]. WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: WAY100135 | WAY100135 Dihydrochloride | WAY 100135 | WAY 100135 dihydrochloride | WAY-100135 Dihydrochloride | WAY-100135 | WAY100135 dihydrochloride | WAY 100135 Dihydrochloride

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