戈米辛J T3904
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 66280-25-9 | ¥5,850.00 | 询底价 |
1 mg | 66280-25-9 | ¥822.00 | 询底价 |
2 mg | 66280-25-9 | ¥1,260.00 | 询底价 |
100 mg | 66280-25-9 | ¥10,900.00 | 询底价 |
5 mg | 66280-25-9 | ¥2,390.00 | 询底价 |
10 mg | 66280-25-9 | ¥3,620.00 | 询底价 |
50 mg | 66280-25-9 | ¥8,120.00 | 询底价 |
1 mL | 66280-25-9 | ¥1,980.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Gomisin J
描述: Gomisin J 是在五味子中发现的小分子量木脂素,具有血管舒张活性,在非酒精性脂肪性肝病方面有研究潜力。 它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达,从而抑制脂质积累。
体外活性: Gomisin J attenuated lipid accumulation in OA-induced HepG2 cells.?It also suppressed the expression of lipogenic enzymes and inflammatory mediators and increased the expression of lipolytic enzymes in OA-induced HepG2 cells.?Furthermore, the use of specific inhibitors and fetuin-A siRNA and liver kinase B1 (LKB1) siRNA transfected cells demonstrated that gomisin J regulated lipogenesis and lipolysis via inhibition of fetuin-A and activation of an AMP-activated protein kinase (AMPK)-dependent pathway in HepG2 cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (128.71 mM)
关键字: Ca channels | Ca2+ channels | Inhibitor | AMPK | AMP-activated protein kinase | inhibit | Gomisin J | Calcium Channel
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相关库: Anti-Aging Compound Library | Anti-Cancer Metabolism Compound Library | Membrane Protein-targeted Compound Library | Anti-Metabolism Disease Compound Library | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Lipid Metabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途