艾米替诺福韦 T39043

Product Introduction
Bioactivity


英文名: Tenofovir amibufenamide

描述: Tenofovir amibufenamide (HS-10234) (HS-10234) 是一种 Tenofovir 前药，是一种具有口服活性的抗病毒化合物。Tenofovir amibufenamide 对乙型肝炎病毒 (HBV)具有抑制作用，可用于慢性乙型肝炎 (CHB) 研究。

体外活性: TMF and TAF exhibited significantly stronger inhibition of HBV DNA replication than did TDF in HBV-positive HepG2.2.15 cells. The anti-HBV activity of TMF was slightly stronger than TAF after 9 days of treatment (EC50 7.29 ± 0.71 nM vs. 12.17 ± 0.56 nM). The callback effects of the three TFV ester prodrugs were ranked as TMF > TAF > TDF. These advantages of TMF were believed to be attributed to its greater bioavailability in preclinical animals (SD rats, C57BL/6 mice and beagle dogs) and better target loading, especially in terms of the higher hepatic level of the pharmacologically active metabolite TFV-DP, which was tightly related to anti-HBV efficacy. [1]

体内活性: Safety was evaluated thoroughly focusing on bone, renal, and metabolic parameters between TMF (25 mg, for 96 weeks) and TDF group. Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted, while a smaller decline of which was seen in the TMF group than in the TDF group (p=0.01). For bone mineral density, patients receiving TMF displayed significantly lower reduction levels in the densities of spine, hip, and femur neck at week 96 than those receiving TDF. In addition, the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend. TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 180.0 mg/mL (367.0 mM)


关键字: HS10234 | Tenofovir amibufenamide | HS 10234

相关产品: Canocapavir | Cetylpyridinium Chloride | Niranthin | Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside | 4,5-Dicaffeoylquinic acid | HBV-IN-41 | Adefovir dipivoxil | AT-130 | Telbivudine | Osalmid

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Anti-Viral Compound Library | Bioactive Compound Library

艾米替诺福韦 T39043信息由TargetMol中国为您提供，如您想了解更多关于艾米替诺福韦 T39043报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途