Cyclotriazadisulfonamide T39264
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 182316-44-5 | ¥2,950.00 | 询底价 |
2 mg | 182316-44-5 | ¥2,570.00 | 询底价 |
10 mg | 182316-44-5 | ¥5,890.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Cyclotriazadisulfonamide
描述: Cyclotriazadisulfonamide (CADA) is a specific inhibitor of HIV entry that targets CD4. It functions by preventing the co-translational translocation of human CD4 (huCD4) into the endoplasmic reticulum (ER) lumen through a mechanism dependent on the signal peptide (SP).
体外活性: Cyclotriazadisulfonamide (CADA) significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1]. Cyclotriazadisulfonamide (CADA) exhibits an EC 50 of 0.4 μg/mL for CD4 in MO-DC cells. Treatment of MO-DC with 10 μg/mL of CADA results in 83% downregulation of cell surface CD4, an effect that is similar to that observed for CADA treatment of CD4 + T cells[1]. CADA prevents MT-4 cells from HIV-1 and SIV infection (EC 50 are 0.7 and 1.2 g/ml, respectively)[1]. Western Blot Analysis[1]Cell Line: MO-DCs. Concentration: 0.4 μg/mL. Incubation Time: 24 h. Result: A 50% reduction in CD4 expression was obtained.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclotriazadisulfonamide T39264信息由TargetMol中国为您提供,如您想了解更多关于Cyclotriazadisulfonamide T39264报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途