Ledaborbactam etzadroxil T39288

Product Introduction
Bioactivity


英文名: Ledaborbactam etzadroxil

描述: Ledaborbactam etzadroxil (VNRX-7145) is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes.

体内活性: Upon dosing the Ledaborbactam etzadroxil (VNRX-7145) in mice, dogs, and monkeys, Ledaborbactam etzadroxil (5-10 mg/kg) demonstrates the most consistent oral bioavailability across species (F = 61-82%)[1]. In intestinal S9, Ledaborbactam etzadroxil is rapidly cleaved with short half-lives in all species with the exception of beagle dogs. The half-life in human plasma is short at about 11 min, which is closer to what was observed in the rodent species compared to the longer half-lives in dogs (43.9 min) and monkeys (22.0 min)[1]. In vivo efficacy is demonstrated in a lethal murine septicemia model by dosing Ledaborbactam etzadroxil (orally) with Ceftibuten. The ED 50 value of 12.9 mg/kg[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: VNRX7145 | VNRX 7145 | Ledaborbactam etzadroxil

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途