FF-10502 T39290

Product Introduction
Bioactivity


英文名: FF-10502

描述: FF-10502 is a pyrimidine nucleoside antimetabolite and a structural analog of Gemcitabine. This compound effectively inhibits DNA polymerase α and β, demonstrating potent anticancer activity by targeting dormant cells.

体外活性: FF-10502 (0.1 nM-10 μM; 72 hours) shows the growth inhibition of pancreatic cancer cell lines, with IC 50 s of 59.9 nM, 39.6 nM, 68.2 nM, and 331.4 nM for BxPC-3, SUIT-2, Capan-1, and MIA PaCa-2 cells, respectively[1]. Cell Viability Assay[1]Cell Line: Human pancreatic cancer cell lines (BxPC-3, SUIT-2, Capan-1, and MIA PaCa-2) Concentration: 0.1 nM to 10 μM Incubation Time: 72 hours Result: Inhibited the growth of pancreatic cancer cell lines.

体内活性: FF-10502 (120-480 mg/kg; i.v; once weekly; for 4 weeks) shows an antitumor effect in a mouse xenograft model with the subcutaneously implanted human pancreatic cancer cell line Capan-1[1]. Animal Model: Five-week-old female nude mice (BALB/c-nu/nu) injected with Capan-1 cells[1]. Dosage: 120 mg/kg, 240 mg/kg, 360 mg/kg, and 480 mg/kg Administration: Tail vein injection; once weekly; for 4 weeks Result: Suppressed tumor growth in a dose-dependent manner in mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: FF 10502 | FF10502 | FF-10502

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途