Belumosudil mesylate T39555

Product Introduction
Bioactivity


英文名: Belumosudil mesylate

描述: Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC 50 s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties.

体外活性: Belumosudil (SLx-2119; 40 μM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. The microarray hybridized with aRNA from HMVEC treated with Belumosudil, shows a 5-times higher background than the other arrays[1].

体内活性: Belumosudil (KD-025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Belumosudil mesylate | KD-025 Mesylate | KD 025 Mesylate | KD025 Mesylate | Belumosudil Mesylate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途