化合物ICA069673 T3959

Product Introduction
Bioactivity


英文名: ICA-069673

描述: ICA-069673是一种KCNQ2/Q3钾通道激活剂，IC50值为0.69 μM。

体外活性: ICA-069673 is 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5. It has no inhibitory against a panel of cardiac ion channels (IC50> 30 μM for hERG, Nav1.5, L type channels, and KCNQ1). ICA-069673 (10 μM) has no activity on GABA(A) gated channels. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, a 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (185.43 mM)


关键字: Potassium Channel | ICA-069673 | KcsA | ICA 069673 | inhibit | Inhibitor

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相关库: Ion Channel Inhibitor Library | Potassium Channel Blocker Library | ReFRAME Related Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | NO PAINS Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途