化合物VUF10460 T3963

Product Introduction
Bioactivity


英文名: VUF10460

描述: VUF10460 是一种非咪唑组胺 H4 受体激动剂，与大鼠H4受体结合的pKi 值为7.46。

体外活性: UF10460与大鼠H3和H4受体结合，其pKi值分别为5.75和7.46，而VUF10460对大鼠H4受体相比H3受体显示出大约50倍的选择性[1]。

体内活性: HCl引发的大鼠胃损伤在H4受体激动剂VUF10460的作用下显著增强。此效果不受H4受体拮抗剂JNJ7777120[1]的改变。VUF10460对大鼠H(4)受体相较于H(3)受体展现出约50倍的选择性。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 36 mg/mL


关键字: Inhibitor | VUF 10460 | inhibit | Histamine Receptor | VUF10460 | VUF-10460

相关产品: ROS 234 dioxalate | Zotepine | Zeorin | Chloropyramine hydrochloride | Alcaftadine | Histamine Phosphate | H3R-IN-1 Hydrochloride | H4R antagonist 1 | Cetirizine D4 | Clobenpropit dihydrobromide

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Histamine & Melatonin Receptor-Targeted Compound Library | Anti-Parkinson's Disease Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Anti-Obesity Compound Library | Target-Focused Phenotypic Screening Library | Nonsteroidal Anti-Inflammatory Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途