Loreclezole hydrochloride T39708

Product Introduction
Bioactivity


英文名: Loreclezole hydrochloride

描述: Loreclezole hydrochloride, an antiepileptic compound, functions as a selective modulator of GABA A receptors. Specifically, it acts as a positive allosteric modulator on receptors containing β2 or β3-subunits.

体内活性: Loreclezole (10, 25, 50 or 75 mg/kg, i.p. 60 min before measurement of seizure threshold ) results in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later. Loreclezole also has the least effect on loss of muscle tone as measured by the “pull-up” test[3]. Animal Model: Adult male Lister Hooded rats[3]. Dosage: 10, 25, 50 or 75 mg/kg. Administration: IP, 60 min before measurement of seizure threshold. Result: Resulted in a dosedependent rise in seizure threshold as measured by the dose of pentylenetetrazolrequired to produce a convulsion 60 min later.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: R-72063 Hydrochloride | R72063 Hydrochloride | Loreclezole Hydrochloride | R 72063 Hydrochloride

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途