nAChR agonist CMPI hydrochloride T39771

Product Introduction
Bioactivity


英文名: nAChR agonist CMPI hydrochloride

描述: nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4) 3 (β2) 2 nAChR to ACh (10 μM) with an EC 50 of 0.26 μM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.

体外活性: CMPI (0.01-10 μM) potentiates (α4) 3 (β2) 2 (low ACh sensitivity) but not (α4) 2 (β2) 3 (high ACh sensitivity) nAChRs in Xenopus laevis oocytes[1]. CMPI (0.01-10 μM) inhibits (α4) 2 (β2) 3 , human muscle and Torpedo nAChRs with IC 50 s of 0.6, 0.7 and 0.2 μM, respectively in Xenopus oocytes[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: nAChR agonist CMPI hydrochloride | nAChR agonist CMPI Hydrochloride

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