anti-TNBC agent-1 T39815

Product Introduction
Bioactivity


英文名: anti-TNBC agent-1

描述: anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells.

体外活性: anti-TNBC agent-1 (compound 7) exhibits potent activity against MDA-MB231, SUM-159, MCF-7, Bcap-37, 4T1 cells with IC 50 values ranging from 0.20 μM to 0.27 μM. anti-TNBC agent-1 shows 11.6- to 18.6-fold improvement comparing to that of the parent compound parthenolide with IC50 values of 2.68-4.63 μM. anti-TNBC agent-1 is more active than the positive control drug Adriamycin (ADR)[1]. anti-TNBC agent-1 (2 μM and 5 μM; 48 hours; SUM-159 cells) exhibits significant stronger effect on induction of cell apoptosis compared with that of Parthenolide[1]. anti-TNBC agent-1 has selective cytotoxicity against breast cancer cells (IC 50 =0.22 μM) being compared with 3T3 cells (IC 50 =8.13 μM)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: anti TNBC agent 1 | antiTNBC agent1 | anti-TNBC agent-1

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途