IDO1-IN-7 T39888

Product Introduction
Bioactivity


英文名: IDO1-IN-7

描述: IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.

体外活性: IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC 50 of 330 nM[1]. IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity[1]. IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC 50 =14,000 nM)[1].

体内活性: IDO1-IN-7 (10 mg/kg; p.o.) shows C max =10.0 μM, AUC 0-8 h =27.1 μM*h, t 1/2 =1.4 h in mouse[1]. Animal Model: Mouse[1]Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: Oral administration Result: C max (10.0 μM), AUC 0-8 h (27.1 μM*h), t 1/2 (1.4 h)

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: IDO1IN7 | IDO-1-IN-7 | IDO1 IN 7

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途