XZ739 T39909

Product Introduction
Bioactivity


英文名: XZ739

描述: XZ739 is a Cereblon-dependent PROTAC BCL-XL degrader, targeting a member of the Bcl-2 family, with a DC50 value of 2.5 nM in MOLT-4 cells after 16 hours of treatment. Additionally, XZ739 elicits cell death via caspase-mediated apoptosis.

体外活性: XZ739 (0.001-10 μM; 48 hours) potently reduces the viability of T-ALL MOLT-4, B-ALL RS4; 11, SCLC NCI-H146 cells, and platelets after 48 h treatment with IC 50 s of 10.1, 41.8, 25.3, and 1217 nM, respectively. XZ739 has >100-fold selectivity for MOLT-4 cells over human platelets[1]. XZ739 (1.2-300 nM; 16 hours) induces BCL-XL degradation in MOLT-4 cells[1]. The BCL-XL degradation induced by XZ739 in MOLT-4 is rapid, starting within 2 h; and 8 h after XZ739 treatment, more than 96% of the BCL-XL is degraded with 100 nM of XZ739[1]. Cell Viability Assay[1]Cell Line: Human platelets and MOLT-4 cells Concentration: 0.001, 0.01, 0.1, 1, and 10 μM Incubation Time: 48 hours Result: IC 50 values were 10.1 nM and 1217 nM for MOLT-4 cells and platelets, respectively. Western Blot Analysis[1]Cell Line: MOLT-4 cells Concentration: 1.2, 3.7, 11, 33, 100, 300 nM Incubation Time: 16 hours Result: Dose-dependently induced BCL-XL degradation.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: XZ 739 | XZ-739

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途