PROTAC PD-1/PD-L1 degrader-1 T40112
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 2447066-37-5 | 面议 | 询底价 |
100 mg | 2447066-37-5 | 面议 | 询底价 |
5 mg | 2447066-37-5 | ¥7,320.00 | 询底价 |
10 mg | 2447066-37-5 | ¥11,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PROTAC PD-1/PD-L1 degrader-1
描述: PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
体外活性: PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%[1]. PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively[1]. Western Blot Analysis[1]Cell Line: MDA-MB-231 cells Concentration: 1-10 μM Incubation Time: 24 hours Result: Reduced PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: PROTAC PD 1/PD L1 degrader 1 | PROTAC PD1/PDL1 degrader1 | PROTAC PD-1/PD-L-1 degrader-1
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途