XVA143 T40274

Product Introduction
Bioactivity


英文名: XVA143

描述: XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo. XVA143 is an antagonist of both mouse and human CR3, inhibits the ability of P. gingivalis to persist in the mouse host and cause periodontal bone loss.

体外活性: XVA143 (1 μM) completely abolishes binding of ICAM-1 to LFA-1 in Mn 2+ and Mg 2+ /EGTA, with no hint of agonism[1].XVA143 restores rolling of the α L -E310A β 2 mutant by inducing extension of α L[2]. Cell Viability Assay[1]Cell Line: K562 cells. Concentration: 0, 0.2, 0.5 and 1 μM. Incubation Time: Result: Potent against the weakest activator (2 mM Mg 2+ /1 mM EGTA, IC 50 ~10 -3 nM) and least potent against the strongest activator (1 mM Mn 2+ , IC 50 ~10 -3 nM). Cell Viability Assay[1]Cell Line: Wild-type murine lymphocytes[1]. Concentration: 100 μM. Incubation Time: Result: Induced a 50% increase in rolling fraction compared to vehicle-treated control cells ((from 27±5% to 41±7%).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: XVA-143 | XVA 143

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途