乙氢去甲奎宁盐酸盐 T40417

Product Introduction
Bioactivity


英文名: Ethylhydrocupreine hydrochloride

描述: Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物，具有抗菌作用，可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性，对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。

体外活性: The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). For all three strains studied, the exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold [2].

体内活性: The highest tolerated dose of ethylhydrocupreine hydrochloride for guinea pigs by intrapleural injection is about 0.2 to 0.3 cc. of a 1:100 solution per 100 gm. of weight, corresponding to 2 to 3 cc. of solution or 0.02 to 0.03 gm. of the drug per kilo of weight. The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs [1] .

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 50 mg/mL (132.65 mM)
DMSO : 125 mg/mL (331.64 mM)


关键字: taste | Optochin Hydrochloride | Ethylhydrocupreine hydrochloride | ggTas2r1 | Ethylhydrocupreine Hydrochloride | bitter | antimalarial | inhibit | ggTas2r7 | Optochin | bactericidal | Antimicrobial | Inhibitor | S. pneumoniae | Parasite | Ethylhydrocupreine | Bacterial | ggTas2r2

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相关库: Bioactive Compounds Library Max | Anti-Parasitic Compound Library | Anti-Bacterial Compound Library | Bioactive Compound Library

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