腺苷三磷酸二钾盐 T40526

Product Introduction
Bioactivity


英文名: ATP dipotassium

描述: ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation.

体外活性: ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4]. ATP dipotassium promotes neutrophil chemotaxis in vitro[4].

体内活性: ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4]Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial ( E. coli ) challenge Result: Protected mice from bacterial infection.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: ATP dipotassium | ATP

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途