Tasisulam sodium T40596
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 519055-63-1 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Tasisulam sodium
描述: Tasisulam is an anti-cancer compound that induces apoptosis through the intrinsic pathway, leading to the release of cytochrome c and caspase-dependent cell death. Additionally, tasisulam inhibits mitotic progression and triggers vascular normalization.
体外活性: Tasisulam sodium (200 nM-200 μM; 48 hours) induces an antiproliferative response across a wide range of tumor histologies with EC 50 s of 10 μM and 25 μM for Calu-6 and A-375 cell lines, respectively[1]. Tasisulam sodium (25, 50 μM; 72 hours) induces a concentration-dependent increase in 4N DNA and G2-M accumulation[1]. Tasisulam sodium (200 nM-200 μM; 48 hours) induces apoptosis in a broad range of in vitro cancer cell models[1]. Tasisulam sodium also blocks VEGF, epidermal growth factor, and fibroblast growth factor-induced endothelial cell cord formation[1]. Cell Proliferation Assay[1]Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 nM-200 μM Incubation Time: 48 hours Result: Induced an antiproliferative response across a wide range of tumor histologies with EC 50 s is 10 μM and 25 μM, respectively. Cell Cycle Analysis[1]Cell Line: Calu-6 and A-375 cell lines Concentration: 25, 50 μM Incubation Time: 72 hours Result: Induced a concentration-dependent increase in 4N DNA and G2-M accumulation. Apoptosis Analysis[1]Cell Line: Calu-6 non-small cell lung carcinoma and A-375 melanoma models Concentration: 200 nM-200 μM Incubation Time: 48 hours Result: Induced apoptosis in a broad range of in vitro cancer cell models.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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