化合物Manganese(salen) chloride T40612

Product Introduction
Bioactivity


英文名: Manganese(salen) chloride

描述: Manganese(salen) chloride (EUK-8) 是超氧化物歧化酶和过氧化氢酶的一种模拟物，具有氧自由基清除性能。它可减轻内毒素血症猪的急性肺损伤。

体外活性: Manganese(salen) chloride（25 μM；24-72小时）能保护器官型海马切片免受β-AP诱导的神经毒性，同时完全阻断β-AP诱发的自由基积累和脂质过氧化[2]。

体内活性: Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant [3] . Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice [3] Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. Furthermore, because antioxidant treatment protected both the oxidative stress-prone Hq mouse model and WT mice against pressure overload-induced maladaptive left ventricular remodeling and cardiac decompensation, it may be useful as a novel therapeutic tool in the treatment of human heart failure.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 8.33 mg/mL (23.35 mM)


关键字: Manganese(salen) | inhibit | dismutase | catalase | oxyradical | mimetic | Manganese(salen) Chloride | Inhibitor | antioxidant | superoxide | Reactive Oxygen Species | Manganese(salen) chloride | scavenging | EUK8 | EUK 8

相关库: Antioxidant Compound Library | Bioactive Compounds Library Max | Cuproptosis Compound Library | Bioactive Compound Library

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