化合物KG5 T41003
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 877874-85-6 | ¥1,800.00 | 询底价 |
50 mg | 877874-85-6 | ¥5,330.00 | 询底价 |
25 mg | 877874-85-6 | ¥3,680.00 | 询底价 |
1 mg | 877874-85-6 | ¥478.00 | 询底价 |
100 mg | 877874-85-6 | ¥7,530.00 | 询底价 |
5 mg | 877874-85-6 | ¥1,130.00 | 询底价 |
1 mL | 877874-85-6 | ¥1,330.00 | 询底价 |
Product Introduction
Bioactivity
英文名: KG5
描述: KG5 是 PDGFRβ 和 B-Raf 的双重变构抑制剂,对 PDGFRβ 和 PDGFRα 的 Kd 分别为 520 nM 和 300 nM。 KG5 抑制 FLT3、KIT 和 c-Raf,具有抗癌和抗血管生成活性。
体外活性: KG5 inhibits FLT3 and KIT at 52 and 170 nM, respectively. In endothelial cells stimulated with bFGF or VEGF, KG5 (5 μM) inhibits phosphorylation of MEK and ERK. KG5 inhibits vascular smooth muscle cells (VSMCs) and endothelial cell viability with EC50 values of 0.59 μM and 0.54 μM, respectively. KG5 selectively blocks S338 phosphorylation, yet does not influence S259[1].
体内活性: KG5 (1 μM) disrupts a late step in angiogenesis during zebrafish embryogenesis. In male Nu/Nu mice injected with SN12C-RFP cells, KG5 (100 mg/kg; oral) prevents tumor growth. KG5 (50 mg/kg; i.p.) completely blocks angiogenesis in mice injected with Matrigel containing bFGF with a Cmax of 3.6 μg/mL, T1/2 of 11.5 h, and an AUC0-12h of 14.7 μg•h/mL[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 95 mg/mL (206.77 mM)
关键字: B-Raf | antiangiogenic | KIT | c-Kit | CD135 | Raf kinases | Raf | PDGFR | Cluster of differentiation antigen 135 | Platelet-derived growth factor receptor | Fms like tyrosine kinase 3 | metastasis | c-Raf | FLT3 | PDGFRβ | inhibit | anticancer | phosphorylation | SCFR | Inhibitor | KG 5 | KG-5 | CD117 | KG5
相关产品: TAK-632 | LY3009120 | CCT241161 | GSK2008607 | SB-590885 | Dabrafenib | Raf inhibitor 1 | Regorafenib Hydrochloride | K-Ras(G12C) inhibitor 9 | Encorafenib
相关库: Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Anti-Colorectal Cancer Compound Library | Anti-Obesity Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Active Compound Library
化合物KG5 T41003信息由TargetMol中国为您提供,如您想了解更多关于化合物KG5 T41003报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途