Lonodelestat T41043

Product Introduction
Bioactivity


英文名: Lonodelestat

描述: Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE).

体内活性: Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice[1]. Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001)[1]. Animal Model: Ten-week-old male C57BL/6j mice[1]. Dosage: 0.05, 0.2, 0.5 and 5 mg/kg. Administration: Administered intranasally (i.n.) 15 minutes before HNE (30 UI, i.n.). Result: Reduced the inflammatory processes of ALI in HNE treated mice.

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: POL-6014 | POL 6014 | Lonodelestat

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途