化合物SB 271046 hydrochloride T4118

Product Introduction
Bioactivity


英文名: SB 271046 hydrochloride

描述: SB 271046 hydrochloride (SB 271046A) 是高效、选择性和具有口服活性的5-HT6受体拮抗剂，对大鼠、猪和人的pKi 分别为 9.02、8.55 和 8.81。它增加额叶皮层中的细胞外天冬氨酸和谷氨酸并表现出抗惊厥活性，EC50为 0.16 μM。它对 5-HT6 受体、结合位点和离子通道的选择性超过 200 倍。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (92.13 mM)


关键字: oral | test | Serotonin Receptor | SB271046 | 5-HT Receptor | Inhibitor | inhibit | 5-hydroxytryptamine Receptor | SB-271046 | SB 271046 Hydrochloride | SB 271046 hydrochloride | SB 271046 | channels | anticonvulsant | SB271046 Hydrochloride | SB-271046 Hydrochloride | selective | MEST

相关产品: GTS-21 dihydrochloride | Cinchonidine | Org 13011 | Ketanserin tartrate | Lumateperone | WAY-100635 Monomaleate | Homoeriodictyol | FFN246 | Brexpiprazole | Amitriptyline

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Highly Selective Inhibitor Library | Orally Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途