替诺福韦艾拉酚胺富马酸盐 T41249

Product Introduction
Bioactivity


英文名: Tenofovir alafenamide fumarate

描述: Tenofovir alafenamide fumarate (GS-7340 fumarate) 是一种可口服的 Tenofovir 前体化合物。Tenofovir alafenamide fumarate 具有抗 HIV 活性，可用于预防 HIV 感染。

体外活性: Tenofovir alafenamide fumarate antiviral activity was similar in all cell types, ranging from 5 to 7 nM, whereas CC50 varied from 4.7 to 42 μM for MT-4 and MT-2 cells. The antiviral activity of TAF was evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 M group subtypes A to G, as well as group N and O isolates. Overall, TAF EC50 ranged from 0.1 to 12 nM, with an average EC50 of 3.5 nM, compared to an average EC50 of 11.8 nM for AZT, used as an internal control, for 29 major HIV-1 isolates tested in PBMC. For HIV-2 isolates, the average EC50 is 1.8 nM for TAF and 6.4 nM for AZT.[2]

体内活性: Tenofovir alafenamide fumarate（GS-7340 fumarate）作为Tenofovir的酰胺前药，相较于Tenofovir disoproxil fumarate（TDF）[1]，具有良好的口服生物利用度并增强了血浆稳定性。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 25 mg/mL (42.19 mM)
DMSO : 200 mg/mL (337.53 mM)


关键字: Tenofovir alafenamide Fumarate | GS-7340 Fumarate | GS7340 Fumarate | GS 7340 Fumarate

相关产品: Zalcitabine | Azulene | Darunavir | Enfuvirtide acetate | CA inhibitor 1 | Andropanolide | ONX-0914 | Chloroquine | Panobinostat | Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | EMA Approved Drug Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途