化合物 Riluzole hydrochloride T41265
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 850608-87-6 | ¥255.00 | 询底价 |
5 mg | 850608-87-6 | ¥185.00 | 询底价 |
2 mg | 850608-87-6 | ¥128.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Riluzole hydrochloride
描述: Riluzole hydrochloride 是一种抗惊厥药物,属于依赖于使用的钠通道阻滞剂家族,也可以抑制 GABA 摄取,IC50值为 43 μM。
体外活性: Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC 50 of 43 μM. At 20 μM, Riluzole hydrochloride inhibits peak autaptic IPSCs only slightly but reliably prolongs IPSCs. It is also found that Riluzole hydrochloride causes a strong, concentration-dependent, readily reversible enhancement of responses to 2 μM GABA. At higher concentrations of Riluzole hydrochloride, especially 300 μM, GABA currents exhibit apparent desensitization during prolonged co-exposure to 2 μM GABA and Riluzole hydrochloride. The EC 50 of Riluzole hydrochloride potentiation of GABA responses is about 60 μM [1].
体内活性: In normal na ve rats, systemic injection of Riluzole hydrochloride (8 mg/kg, i.p.; n=6 rats) reduces the duration of ultrasonic but not audible vocalizations evoked by noxious stimulation of the knee joint compare to vehicle tested in the same rats (P<0.05). Systemic application of Riluzole hydrochloride (8 mg/kg, i.p.; n=19 rats) decreases the vocalizations of arthritic rats compare to predrug and vehicle significantly (P<0.05 to 0.001). Riluzole hydrochloride administered into the CeA significantly decreases the duration of audible and ultrasonic vocalizations evoked by noxious stimulation of the knee compare to predrug values (n=8 rats; P<0.05 to 0.01) [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Riluzole Hydrochloride | Riluzole hydrochloride
化合物 Riluzole hydrochloride T41265信息由TargetMol中国为您提供,如您想了解更多关于化合物 Riluzole hydrochloride T41265报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途