L-半胱氨酸亚磺酸一水合物 T41301

Product Introduction
Bioactivity


英文名: L-Cysteinesulfinic acid monohydrate

描述: L-Cysteinesulfinic acid monohydrate 是代谢型谷氨酸受体 (mGluRs) 的有效激动剂，可以作用于 mGluR1，mGluR2，mGluR5，mGluR4，mGluR6 和 mGluR8，pEC50分别为 3.92，3.9，4.6，2.7，4.0，和 3.94。

体外活性: L-Cysteinesulfinic acid (monohydrate) is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA (monohydrate) is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA (monohydrate) selectively activates the PLD-coupled receptor. 1 mM L-CSA (monohydrate) induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA (monohydrate) elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA (monohydrate) is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA (monohydrate)-induced increases in cell firing[1].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 120 mg/mL (701.06 mM)


关键字: L Cysteinesulfinic acid monohydrate | LCysteinesulfinic acid monohydrate | Metabotropic glutamate receptors | Inhibitor | inhibit | L-Cysteinesulfinic acid Monohydrate | L-Cysteinesulfinic acid | mGluR

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相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Mouse Metabolite Compound Library | Bioactive Compound Library

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