化合物BPTU T4132

Product Introduction
Bioactivity


英文名: BPTU

描述: BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂，能够阻断位于胃肠道神经肌肉接头的 P2Y1受体，具有抗血栓活性。

体内活性: Octreotide-treated groups show a significant reduction in the tumor volume when compared with saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.). Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group. Octreotide-PPSG appears to inhibit the expression of SSTR2 and SSTR5 to a greater extent than that of Octreotide-soln treated group. A test dose of octreotide acetate significantly decreases the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetatea (5 mg intramuscular, q 4 wk) is initiated.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (44.9 mM)


关键字: antithrombotic | BPTU | thrombosis | BMS646786 | P2Y Receptor | inhibit | BMS 646786 | Inhibitor

相关产品: AZD1283 | Clopidogrel hydrogen sulfate | Clopidogrel | 4-Thiouridine 5′-triphosphate tetralithium | Ticagrelor metabolite M5 | Uridine-5'-diphosphate disodium salt | NF546 hydrate | Regrelor disodium | PPTN | Prasugrel

相关库: Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Fluorochemical Library | Neuronal Signaling Compound Library | Inhibitor Library | GPCR Compound Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library | Covalent Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途