化合物R162 T4173
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 64302-87-0 | ¥728.00 | 询底价 |
1 mL | 64302-87-0 | ¥697.00 | 询底价 |
25 mg | 64302-87-0 | ¥2,180.00 | 询底价 |
10 mg | 64302-87-0 | ¥1,130.00 | 询底价 |
100 mg | 64302-87-0 | ¥4,720.00 | 询底价 |
2 mg | 64302-87-0 | ¥432.00 | 询底价 |
50 mg | 64302-87-0 | ¥3,290.00 | 询底价 |
1 mg | 64302-87-0 | ¥297.00 | 询底价 |
500 mg | 64302-87-0 | ¥9,780.00 | 询底价 |
Product Introduction
Bioactivity
英文名: R162
描述: R162 是谷氨酸脱氢酶 (GDH1/GLUD1) 抑制剂,具有抗癌的活性。
体外活性: R162通过降低细胞内延胡索酸水平、抑制GDH1活性、增加ROS水平以及减少H1299和MDA-MB231细胞中的细胞增殖,从而减弱GPx活性。R162抑制人类癌细胞的肿瘤生长潜力及细胞增殖。
体内活性: In xenograft tumor mouse models, R162 (30 mg/kg/day, i.p.) does not cause a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties. Compared with control mice, R162 (20 mg/kg/day) markedly decreases tumor growth and masses and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 3.85 mg/mL (14.55 mM)
关键字: R162 | inhibit | Inhibitor | R 162 | R-162
相关产品: Benzyl alcohol | Ribavirin | Tenuifoliside C | Galloflavin | BRD9185 | CBR-5884 | Mutant IDH1-IN-1 | AZD7545 | Agrimonolide | Disulfiram
相关库: Anti-Aging Compound Library | Anti-Cancer Metabolism Compound Library | Oxidation-Reduction Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途