化合物TD198946 T4193
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 364762-86-7 | ¥898.00 | 询底价 |
10 mg | 364762-86-7 | ¥2,880.00 | 询底价 |
25 mg | 364762-86-7 | ¥5,220.00 | 询底价 |
50 mg | 364762-86-7 | ¥6,910.00 | 询底价 |
1 mL | 364762-86-7 | ¥1,960.00 | 询底价 |
2 mg | 364762-86-7 | ¥1,250.00 | 询底价 |
5 mg | 364762-86-7 | ¥1,820.00 | 询底价 |
Product Introduction
Bioactivity
英文名: TD-198946
描述: TD-198946 是一种高效的软骨形成剂,是一种噻吩并唑衍生物。
动物实验: For intra-articular injection, TD-198946 is dissolved at 100 nM in a solution of 45% 2-hydropropyl-b-cyclodextrin in saline.Mouse: Each of the prevention and repair models had two groups: (1) TD-198946-treated animals and (2) saline-treated animals. In all the mice tested the left knee joints underwent the operation and the right knee joints are sham-operated. Mice are re-anesthetized and given a 10 μL intra-articular injection of TD-198946 or saline immediately after surgery (prevention model) or 4 weeks following surgery (repair model) every 5 days for 8 or 4 weeks, respectively.
体外活性: In cell and metatarsal organ cultures, TD-198946 markedly induces chondrogenic differentiation without promoting hypertrophy. In ATDC5 cells, TD-198946 induces stronger?Col2a1?promoter activity than insulin. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers?Acan?and?Col2a1 (maximum effects: 1-10 μM).
体内活性: TD-198946 can prevent and repair degeneration of the articular cartilage by administered directly into the joint space. TD-198946 regulates Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage. Cartilaginous cell-sheets are generated by culturing human mesenchymal stem cells and canine and mouse costal chondrocytes with TD-198946 on temperature-responsive dishes.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (103.62 mM)
关键字: inhibit | Inhibitor | TD-198946
相关库: Bioactive Compounds Library Max | NO PAINS Compound Library | Bioactive Compound Library
化合物TD198946 T4193信息由TargetMol中国为您提供,如您想了解更多关于化合物TD198946 T4193报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途