化合物SAG hydrochloride T4211
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 2095432-58-7 | ¥497.00 | 询底价 |
1 mL | 2095432-58-7 | ¥1,090.00 | 询底价 |
10 mg | 2095432-58-7 | ¥1,580.00 | 询底价 |
5 mg | 2095432-58-7 | ¥990.00 | 询底价 |
50 mg | 2095432-58-7 | ¥3,970.00 | 询底价 |
25 mg | 2095432-58-7 | ¥2,890.00 | 询底价 |
100 mg | 2095432-58-7 | ¥5,790.00 | 询底价 |
Product Introduction
Bioactivity
英文名: SAG hydrochloride (912545-86-9(free base))
描述: SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) 可作为 SMO 激动剂。
动物实验: Animal Models: RatFormulation: DMSODosages: 2.5 nMAdministration: Intracerebroventricular administration(Only for Reference)
体外活性: SAG regulates Smo activity by binding directly to the Smo heptahelical bundle. [1] SAG induces Smo-dependent signaling through Gli in a GRK2-dependent way. [2] SAG also (1 nM) induces proliferation of neuronal and glial precursors without affecting the differentiation pattern of newly produced cells.
体内活性: In the adult rat hippocampus, the intracerebroventricular administration of SAG (2.5 nM) significantly increases the number of newly generated cells and extends survival of hippocampal cells. [3] In mice, SAG (20 μg/g, i.p.) effectively prevents GC-induced neonatal cerebellar developmental abnormalities.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 38 mg/mL (72.2 mM)
DMSO : 66 mg/mL (125.4 mM)
关键字: SAG hydrochloride (912545 86 9(free base)) | SAG hydrochloride (912545-86-9(free base)) | SAG hydrochloride (912545869(free base))
相关产品: Glasdegib | SAG dihydrochloride | Naftifine hydrochloride | Taladegib | Vismodegib | Purmorphamine | Ciliobrevin A | TAK-441 | SMANT hydrochloride | SANT-1
相关库: Anti-Aging Compound Library | Anti-Prostate Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Osteogenesis Compound Library | GPCR Compound Library | Reprogramming Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途