5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮 T4215

Product Introduction
Bioactivity


英文名: TCS-PIM-1-4a

描述: TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂，可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系，IC50值为 0.8 μM 至 40 μM。

体外活性: One hour inhibitor treatment (0.5 μM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 μM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 μM with respective inhibitor).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (201.3 mM)


关键字: arrest | Bak | Leukemic | 4E-BP1 | mTORC1 | TCSPIM14a | Pim kinases | TCS PIM 1 4a | Inhibitor | Pim | p27Kip1 | cell-cycle | inhibit | Apoptosis | TCS-PIM-1-4a | Bax

相关产品: Mirdametinib | Isosilybin A | ELR510444 | Mezigdomide | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | D609 | Samuraciclib hydrochloride | Triptonide | AOH1996 | Lonidamine

相关库: HIF-1 Signaling Pathway Compound Library | Anti-Prostate Cancer Compound Library | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | Preclinical Compound Library | Reprogramming Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途