化合物STAT5 Inhibitor T4216

Product Introduction
Bioactivity


英文名: STAT5-IN-1

描述: STAT5-IN-1 (STAT5 Inhibitor) 是STAT5的抑制剂，对 STAT5β 亚型的IC50值为 47 μM。

体外活性: The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins that are implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (170.49 mM)


关键字: STAT-5-IN-1 | STAT5IN1 | inhibit | STAT5-IN-1 | STAT5 IN 1 | Inhibitor | STAT

相关产品: Ascochlorin | Tetramethylcurcumin | Arnicolide D | Curculigoside | STAT3-IN-3 | NT157 | 3-O-Methylgallic acid | Atractylenolide I | Ochromycinone | ENMD-1198

相关库: Anti-Prostate Cancer Compound Library | Transcription Factor-Targeted Compound Library | Anti-Cancer Metabolism Compound Library | Inhibitor Library | Anti-Diabetic Compound Library | Anti-Pancreatic Cancer Compound Library | Reprogramming Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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