3-羟基-1-甲氧基-2-甲基蒽醌 T4237

Product Introduction
Bioactivity


英文名: Rubiadin-1-methyl ether

描述: Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) 是一种巴戟天中的蒽醌类化合物，能够抑制 NF-κB p65 的磷酸化和 IκBα 的降解以及减少 p65 的核转位，阻碍破骨细胞的骨吸收。

体外活性: To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. METHODS AND RESULTS:Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by Rubiadin 1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 μM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). CONCLUSIONS:Thus, these compounds could be beneficial in the treatment of diabetes.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 2.68 mg/mL (10 mM)


关键字: Inhibitor | Nuclear factor-kappaB | Nuclear factor-κB | NF-κB | Rubiadin1methyl ether | Rubiadin 1 methyl ether | inhibit | Rubiadin-1-methyl ether

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相关库: Antioxidant Compound Library | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Covalent Inhibitor Library | Bioactive Compound Library | Anti-infective Natural Product Library | Anti-Infection Compound Library

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