化合物Skp2 Inhibitor C1 T4253

Product Introduction
Bioactivity


英文名: Skp2 Inhibitor C1

描述: Skp2 Inhibitor C1 (SKPin C1)(SKPin C1)是Skp2介导p27降解的特异性抑制剂。

激酶实验: To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored.

体外活性: in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (107.45 mM)


关键字: Ubiquitin conjugating enzyme | E1 activating enzyme | Skp-2 Inhibitor C1 | Skp2 Inhibitor C1 | E1/E2/E3 Enzyme | E3 ligating enzyme | Ubiquitin activating enzyme | SKPin C 1 | E2 conjugating enzyme | Ubiquitin ligase | SKPin C-1 | Inhibitor | inhibit

相关产品: Nutlin-3a | Cbl-b-IN-13 | MD-224 | Avadomide | TAS4464 | C25-140 | TZ9 | Navtemadlin | SZL P1-41 | Heclin

相关库: HIF-1 Signaling Pathway Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | Inhibitor Library | Highly Selective Inhibitor Library | Target-Focused Phenotypic Screening Library | Covalent Inhibitor Library | Bioactive Compound Library

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