化合物PTP1B-IN-2 T4256

Product Introduction
Bioactivity


英文名: PTP1B-IN-2

描述: PTP1B-IN-2 是一种蛋白酪氨酸磷酸酶抑制剂，IC50=50 nM。

激酶实验: The PTP1B enzymatic assay, the total volume of 100 μL per well contains15 nM recombinant PTP1B protein, 2 mM p-nitrophenylphosphonic acid (pNPP), 1 mM dithiothreitol and 1 mM EDTA (pH 6.5). After 30 min incubation at 37℃, end the reaction by addition of 2.5 M NaOH. The hydrolysis product, pNP, is detected at the absorbance at 405 nm.

体外活性: PTP1B-IN-2深入活性位点口袋，与催化位点的关键残基形成多个氢键和疏水作用。在15μM及30μM浓度下，PTP1B-IN-2显著增强胰岛素介导的IRβ磷酸化。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (66.1 mM)


关键字: PTP1B-IN-2 | Inhibitor | PTP-1B-IN-2 | inhibit | PTP1BIN2 | Phosphatase | PTP1B IN 2

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相关库: Anti-Neurodegenerative Disease Compound Library | Anti-COVID-19 Compound Library | Glycometabolism Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Phosphatase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途