化合物CaCCinh-A01 T4330

Product Introduction
Bioactivity


英文名: CaCCinh-A01

描述: CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂，IC50值分别为 10 和 2.1 μM。

细胞实验: Each well of a 96-well plate is washed three times with PBS (200 μL/wash), leaving 50 μL of PBS. Test compounds (including CaCCinh-A01) (0.5 μL) are added to each well at 25 μM final concentration. After 10 min, 96-well plates are transferred to a plate reader for fluorescence assay. Each well is assayed individually for TMEM16A-mediated I- influx by recording fluorescence continuously (400 ms/point) for 2 s (baseline), then 50 μL of a 140 mM I-solution containing 200 μM ATP is added.

体外活性: Tannic acid (100 μM) and CaCCinh-A01 (30 μM) effectively inhibit CaCC current following ATP stimulation[1]. CaCCinh-A01 (0.1/1/10 μM) reduces Calcium-dependent chloride current (38±14, 66±10, and 91±1%). ATP-induced short-circuits currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (158.31 mM)


关键字: TMEM16A | infarction | inhibit | Inhibitor | neurological | CaCCinh-A-01 | CaCCinh-A01 | cerebral artery occlusion | CaCCinhA01 | Cl? Channels | Chloride Channel | CaCCinh A01 | deficit

相关产品: R(+)-IAA-94 | Betaine chloride | ANO1-IN-1 | Meticrane | Talniflumate | Picrotoxinin | DCPIB | Endovion | Selamectin | Isodeoxycholic Acid

相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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