化合物PZM21 T4386
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 1997387-43-5 | ¥981.00 | 询底价 |
100 mg | 1997387-43-5 | ¥4,970.00 | 询底价 |
5 mg | 1997387-43-5 | ¥892.00 | 询底价 |
10 mg | 1997387-43-5 | ¥1,320.00 | 询底价 |
25 mg | 1997387-43-5 | ¥2,160.00 | 询底价 |
50 mg | 1997387-43-5 | ¥3,150.00 | 询底价 |
1 mg | 1997387-43-5 | ¥419.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PZM21
描述: PZM21 是一种有效的选择性 μ 阿片受体激动剂,EC50值为 1.8 nM。
体外活性: At hERG, PZM21 has an IC50 of between 2 and 4 μM, 500- to 1,000-fold weaker than its potency as a μOR agonist. Signalling by PZM21 and other μOR agonists appears to be mediated primarily by the heterotrimeric G protein Gi/o, as its effect on cAMP levels is eliminated by pertussis toxin and no activity is observed in a calcium release assay [1].
体内活性: PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. Unlike morphine, PZM21 is more efficacious for the affective component of analgesia versus the reflexive component and is devoid of both respiratory depression and morphine-like reinforcing activity in mice at equi-analgesic doses. PZM21 displays dose-dependent analgesia in a mouse hotplate assay, with a per cent maximal possible effect (% MPE) of 87% reached 15 min after administration of the highest dose of drug tested [1].PZM21 has a long-lasting analgesic effect on CNS mediated-pain responses, but does not cause respiratory depression and constipation, two key side effects of opioid agonists [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 27.5 mg/mL (76.07 mM)
关键字: Opioid Receptor | Inhibitor | PZM 21 | inhibit | PZM-21 | PZM21
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途