吡螨胺 T4446

Product Introduction
Bioactivity


英文名: Tebufenpyrad

描述: Tebufenpyrad (Comanche) 是一种重要的农业化学杀螨剂，其作用类似于已知的线粒体毒物 rotenone。

体外活性: Exposing rat dopaminergic neuronal cells (N27 cells) to tebufenpyrad and pyridaben for 3 h induced dose-dependent cell death with an EC50 of 3.98 μM and 3.77 μM, respectively. Also, tebufenpyrad and pyridaben (3 μM) exposure induced reactive oxygen species (ROS) generation and m-aconitase damage, suggesting that the pesticide toxicity is associated with oxidative damage. Morphometric image analysis with the MitoTracker red fluorescent probe indicated that tebufenpyrad and pyridaben, as well as rotenone, caused abnormalities in mitochondrial morphology, including reduced mitochondrial length and circularity. Functional bioenergetic experiments using the Seahorse XF96 analyzer revealed that tebufenpyrad and pyridaben very rapidly suppressed the basal mitochondrial oxygen consumption rate similar to that of rotenone. Further analysis of bioenergetic curves also revealed dose-dependent decreases in ATP-linked respiration and respiratory capacity. The luminescence-based ATP measurement further confirmed that pesticide-induced mitochondrial inhibition of respiration is accompanied by the loss of cellular ATP [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (179.72 mM)


关键字: Tebufenpyrad | MK 239 | MK-239

相关产品: Daidzin | Azemiglitazone | 4-methyl-6-phenyl-2H-pyranone | Mito-TEMPO | L-Histidine | Glibenclamide | Leramistat | AMPK activator 11 | IACS-010759 | VLX600

相关库: Anti-Aging Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Anti-Parasitic Compound Library | Metabolism Compound Library | Cuproptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途