化合物Pyridostatin Trihydrochloride T4457

Product Introduction
Bioactivity


英文名: Pyridostatin Trihydrochloride

描述: Pyridostatin Trihydrochloride (RR-82 Trihydrochloride) 是一种 G-四链体稳定剂，Kd 为 490 nM。

细胞实验: Cells are plated at equal confluence and either untreated or treated with 2 μM Pyridostatin continually for 72 h. Cells from individual plates are trypsinized and counted in a Coultercounter. Graphs represent total cell numbers at each time interval and error bars represent S.E.M. Data represent three independent experiments.

体外活性: Pyridostatin hydrochloride is a G-quadruplexe stabilizer, with a Kd of 490 nM. Pyridostatin (PDS) shows neurotoxic activity against primary cortical neurons at 0.01-5 μM, causes DNA double-strand breaks (DSBs) at 1 μM, downregulates BRCA1 in neurons at 1, 2 or 5 μM. Pyridostatin interacts with G-quadruplex motifs in SRC and alters mRNA levels of damaged genes

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (70.82 mM)
H2O : 7.09 mg/mL(10 mM）


关键字: RR 82 Trihydrochloride | RR82 | RR 82 | Pyridostatin | RR82 Trihydrochloride | RR-82 | Pyridostatin Trihydrochloride

相关产品: Moloney murine leukemia virus RT | TMPyP4 tosylate | Remdesivir | SN-38 | Metarrestin | AG-636 | 5-Fluorouridine | Ganoderic acid H | AP-1/NF-κB activation inhibitor 1 | WRN inhibitor 1

相关库: Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | DNA Damage & Repair Compound Library | NO PAINS Compound Library | Bioactive Compound Library

化合物Pyridostatin Trihydrochloride T4457信息由TargetMol中国为您提供，如您想了解更多关于化合物Pyridostatin Trihydrochloride T4457报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途