化合物Pyridostatin TFA T4470

Product Introduction
Bioactivity


英文名: Pyridostatin TFA

描述: Pyridostatin TFA 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。

细胞实验: Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.

体外活性: Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC.Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90 mg/mL (95.88 mM)


关键字: RR82 | neurodegeneration | G-quadruplex | SRC | inhibit | arrest | damage | cycle | DSB | Pyridostatin | RR-82 | Inhibitor | RR 82 | DNA | structure | Pyridostatin TFA

相关产品: Pyridostatin Trihydrochloride | Procaine | Eupatolide | Enrofloxacin | Trifluridine/tipiracil hydrochloride mixture | 3-Acetyl-beta-boswellic acid | MIRA-1 | Carboplatin | AT-130 | T2AA

相关库: Anti-Aging Compound Library | Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途